Gronemann et al. conducted a study to reveal patterns of treatment among patients with treatment-resistant depression (TRD) and major depressive disorder (MDD) characterized by severity and year of diagnosis. Prescriptions including antidepressants and antipsychotics were tracked in the participant group, which comprised adults who had a hospital contact due to major depressive disorder from 1996 to 2015.
It was found that 88% of patients began their treatment with antidepressants or electroconvulsive therapy. Over the study, selective serotonin reuptake inhibitors (SSRIs) were the most frequently used treatment, however, 50.7% of patients changed treatment one or more times. Those patients with treatment-resistant depression used serotonin and noradrenaline inhibitors (SNRIs) as treatment. SSRIs and SNRIs were responsible for the most combinations of treatment irrespective of the presence of treatment-resistant depression, depression severity, or year of diagnosis.
Overall, 15% of patients met the conditions for treatment-resistant depression.
Citation:
Gronemann, F. H., Petersen, J., Alulis, S., Jensen, K. J., Riise, J., Ankarfeldt, M. Z., Solem, E. J., Bødker, N., & Osler, M. (2021). Treatment patterns in patients with treatment-resistant depression in Danish patients with major depressive disorder. Journal of Affective Disorders, 287, 204–213. https://doiorg.ezproxy.library.uvic.ca/10.1016/j.jad.2021.03.029
Open Access
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